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Related Concept Videos

Imprinting01:22

Imprinting

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Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Polymers: Defining Molecular Weight01:01

Polymers: Defining Molecular Weight

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Unlike small molecules with definite molecular weights, polymers are a mixture of individual polymer chains of varying lengths, each with a unique molecular weight.  So, the molecular weight of a polymer is expressed as an average value based on the average size of the polymer chains. The two most common forms of averages used for polymers are the number average molecular weight and weight average molecular weight.
The number average molecular weight (Mn) is the summation of the number...
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Polymers: Molecular Weight Distribution01:10

Polymers: Molecular Weight Distribution

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For any given polymer, the weight average molecular weight (Mw) is higher than, if not equal to, the number average molecular weight (Mn). The only situation in which the weight average molecular weight and the number average molecular weight are equal is when a polymer consists only of chains with equal molecular weight. However, this never happens in a synthetic polymer, since it is difficult to control the polymerization process up to a molecular level with accuracy to a hundred percent.
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Molecular Weight of Step-Growth Polymers01:08

Molecular Weight of Step-Growth Polymers

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Step growth polymerization involves bi or multifunctional monomers. Bifunctional monomers react to form linear step growth polymers, whereas multifunctional monomers react to form non-linear or branched polymers.
As the step-growth polymerization involves step-wise condensation of monomers, the molecular weight also builds up eventually. Consequently, high molecular weight polymers are obtained at the late stages of the polymerization, where 99% of monomers have been consumed.
The extent of the...
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Polymers02:34

Polymers

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Updated: Jan 27, 2026

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces
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Vision for Functionally Decorated and Molecularly Imprinted Polymers in Regenerative Engineering.

John R Clegg1, Marissa E Wechsler1, Nicholas A Peppas1

  • 1University of Texas at Austin, Austin, TX 78712, USA.

Regenerative Engineering and Translational Medicine
|March 26, 2019
PubMed
Summary

Researchers are developing advanced hybrid biomaterials for regenerative engineering. These intelligent materials aim to control cell behavior for tissue repair, addressing key challenges in scaffold design.

Keywords:
BioconjugationDrug deliveryIntelligent biomaterialsMolecular imprintingRegenerative engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Engineering
  • Tissue Engineering

Background:

  • Regenerative engineering requires scaffolds with high porosity for cell infiltration and mechanical integrity to mimic native tissues.
  • Effective delivery of bioactive molecules is crucial for guiding cell organization, proliferation, and differentiation.
  • Developing suitable biomaterials presents significant challenges for materials scientists and engineers.

Purpose of the Study:

  • To highlight recent advancements in scaffold development for regenerative engineering.
  • To propose hybrid materials synthesized via molecular decoration and imprinting as intelligent biomaterials.
  • To discuss the potential of these materials in controlling cellular responses for tissue regeneration.

Main Methods:

  • Review of recent studies on scaffold development in regenerative engineering.
  • Conceptualization of hybrid materials using molecular decoration and molecular imprinting techniques.
  • Exploration of controlled presentation of cell adhesion molecules and growth factors.

Main Results:

  • Hybrid materials offer potential for fine-tuned spatial and temporal control of bioactive molecule presentation.
  • These materials can respond to both cell-driven and external triggers.
  • Recent studies underscore the importance of porosity, mechanical properties, and bioactive molecule delivery in scaffold design.

Conclusions:

  • Intelligent biomaterials, specifically hybrid materials from molecular decoration and imprinting, show promise for regenerative engineering.
  • These materials can precisely control cell interactions, addressing critical needs in tissue repair.
  • Future research will focus on clinical applications and understanding cell-material interactions.