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Development of Clinical Trials to Extend Healthy Lifespan

Jamie N Justice1, Laura Niedernhofer2, Paul D Robbins2

  • 1Internal Medicine Section on Gerontology and Geriatrics, and the Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

Cardiovascular Endocrinology & Metabolism
|March 26, 2019
PubMed

Insights

Scientists are testing the geroscience hypothesis in humans, aiming to delay multiple age-related diseases by targeting the biology of aging. The Targeting Aging with Metformin (TAME) trial is a key step in this research.

Area of Science:

  • Gerontology and Gerontechnology
  • Translational Medicine
  • Biomedical Gerontology

Background:

  • The geroscience hypothesis suggests targeting biological aging can delay multiple age-related diseases.
  • Significant progress in animal models supports this hypothesis, paving the way for human trials.

Purpose of the Study:

  • To describe the development of large-scale clinical trials testing the geroscience hypothesis in humans.
  • To outline the rationale and design of the Targeting Aging with Metformin (TAME) trial as a case study.
  • To provide a perspective on the potential impact of clinical trials targeting aging.

Main Methods:

  • Review of the development of clinical trials designed to test the geroscience hypothesis.
  • Description of the collaborative, consensus-building approach for designing the TAME trial.
  • Outline of a process for selecting biomarkers of biological age for geroscience trials.

Main Results:

  • The TAME trial is the first large-scale clinical trial designed to test the geroscience hypothesis in humans.
  • The trial aims to determine if interventions targeting aging biology can alleviate multiple age-related health conditions simultaneously.
  • A framework for selecting biomarkers of aging is being developed.

Conclusions:

  • Human trials are now feasible to test the geroscience hypothesis.
  • The TAME trial serves as a model for future geroscience-guided clinical trials.
  • Targeting biological aging holds potential for simultaneously delaying multiple age-related diseases.
Keywords:
agingbiomarkersclinical trialsgerosciencehealthspanmulti-morbidity

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