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Updated: Jan 27, 2026

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment
Published on: March 11, 2021
[Long-term individual cognitive stimulation program in patients with mild neurocognitive disorder: a pilot study]
S I Justo-Henriques1, A E Marques-Castro1, P Otero2
1Cediara - Associacao de Solidariedade Social de Ribeira de Fraguas, Aveiro, Portugal.
Long-term individual cognitive stimulation significantly improved cognitive performance and reduced depressive symptoms in patients with mild neurocognitive disorder. The intervention proved effective, feasible, and acceptable, warranting further research.
Area of Science:
- Neuroscience
- Gerontology
- Psychiatry
Background:
- Cognitive stimulation shows promise for mild neurocognitive disorder.
- Previous studies indicated minimal to moderate effects.
- Long-term effects on specific cognitive domains remain unclear.
Purpose of the Study:
- To evaluate the efficacy of a long-term, individual cognitive stimulation intervention.
- To assess the feasibility and acceptability of this intervention.
- To determine the impact on cognitive domains, depressive symptoms, and daily living activities.
Main Methods:
- 30 patients with mild neurocognitive disorder were randomized into intervention (n=15) and control (n=15) groups.
- Intervention group received 88 individual sessions (45 min each, twice weekly).
- Cognitive performance, depressive symptoms, and daily living independence were assessed by external evaluators.
Main Results:
- Significant improvements in overall cognitive performance (d=0.83) and language domain (d=1.50) in the intervention group.
- Reduced depressive symptoms observed in the intervention group (d=0.93).
- High adherence with a mean of 83 sessions attended and a low dropout rate (6.7%).
Conclusions:
- The long-term individual cognitive stimulation intervention is effective, feasible, and acceptable for mild neurocognitive disorder.
- Results support the intervention's potential for improving cognitive function and mood.
- Further validation through a larger randomized controlled trial is recommended.
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