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A Remotely Controlled Transformable Soft Robot Based on Engineered Cardiac Tissue Construct.

Bingzhe Xu1, Xiaomin Han2, Yuwei Hu3

  • 1Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR, China.

Small (Weinheim an Der Bergstrasse, Germany)
|March 26, 2019
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Summary
This summary is machine-generated.

This study introduces a biohybrid robot that transforms its structure using cardiac microtissues. This controllable metamorphosis enables switching locomotive functions and targeted drug delivery for cancer therapy.

Keywords:
biohybrid devicesphotoresponsive systemssoft robotstargeted drug deliverytissue engineeringtransformable robots

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Area of Science:

  • Biohybrid robotics
  • Tissue engineering
  • Biomedical engineering

Background:

  • Organisms exhibit metamorphosis, inspiring reconfigurable robotic systems.
  • Soft robots can achieve multifunctionality through structural transformation.
  • Bio-actuation offers novel control mechanisms for robots.

Purpose of the Study:

  • To develop a tissue-engineered transformable robot inspired by natural metamorphosis.
  • To enable remote control of structural changes for switching locomotive functions.
  • To demonstrate the robot's application in targeted cancer therapy.

Main Methods:

  • Development of a soft robot with a muscular tail fin actuated by cardiac microtissue.
  • Optical triggering for remote control of structural transformation (spread to retracted form).
  • Assessment of changes in bending stiffness and propulsion output.
  • Implementation as a cargo carrier for chemotherapeutic agent delivery.

Main Results:

  • The robot successfully transformed its structure, altering tail fin stiffness and switching locomotive function.
  • Optical triggering provided precise control over the robot's transformation and engine 'on/off' state.
  • The biohybrid robot demonstrated efficacy in programmed delivery of chemotherapeutic agents.
  • The system achieved selective eradication of cancer cells.

Conclusions:

  • The developed tissue-engineered transformable robot showcases unprecedented controllability and responsiveness.
  • This biohybrid system paves the way for advanced intelligent biohybrid robotic systems.
  • The transformable robot concept holds significant potential for targeted drug delivery and other biomedical applications.