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Related Experiment Video

Updated: Jan 27, 2026

Evaluation of Blood Lactate and Plasma Insulin During High-intensity Exercise by Antecubital Vein Catheterization

Evaluation of Blood Lactate and Plasma Insulin During High-intensity Exercise by Antecubital Vein Catheterization

Published on: May 18, 2018

Evaluation of Lactation Compatibility Reference Recommendations.

Amy P Holmes¹, John Brock Harris^2,3, Savannah Ware⁴

¹1 Novant Health Forsyth Medical Center, Winston Salem, NC, USA.

The Annals of Pharmacotherapy

|March 26, 2019

Summary

This summary is machine-generated.

Recommendations for medication safety in breastfeeding vary across resources. LactMed offers the most current and thorough reviews, aiding healthcare providers in making informed decisions for lactating patients.

Keywords:

breastfeeding lactation medication safety

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Area of Science:

Pharmacology
Maternal-Child Health
Evidence-Based Practice

Background:

Multiple drug information resources guide healthcare teams on medication use in breastfeeding patients.
Inconsistent safety and compatibility recommendations exist across these resources.
New Food and Drug Administration (FDA) labeling aims to standardize lactation safety language.

Purpose of the Study:

To evaluate and compare lactation recommendations for selected medications across various drug information resources.
To identify discrepancies in breastfeeding compatibility and safety advice provided by different sources.

Main Methods:

Analysis of breastfeeding recommendations for 19 medications.
Review of 10 distinct drug information resources.
Evaluation of published recommendations for each medication within each resource.

Main Results:

LactMed and Medications and Mothers' Milk 18th Edition listed the most medications as compatible with breastfeeding.
LactMed provided an average of 15.1 references per medication, with a wide range in reference dates (1979-2018).
Significant variations in recommendations and reference dates were observed across the evaluated resources.

Conclusions:

Discrepancies in medication safety recommendations for lactating individuals persist among resources.
LactMed emerges as the most up-to-date and comprehensive resource for medication safety during lactation.
Healthcare professionals should consult multiple resources and critically review supporting evidence when advising on medication use in breastfeeding patients.