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Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma

Rodney Luwor1, Andrew P Morokoff1,2, Stephanie Amiridis1,3

  • 1a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.

Cancer Investigation
|March 26, 2019
PubMed

Insights

Inhibiting dynamin 2 in glioblastoma reduces cancer cell viability and tumor growth. This offers a new therapeutic strategy targeting glioma stem cells for glioblastoma treatment.

Area of Science:

  • Oncology
  • Cell Biology
  • Pharmacology

Background:

  • Glioma stem cells (GSCs) are crucial drivers of glioblastoma (GBM) drug resistance, tumor maintenance, and recurrence.
  • Targeting GSCs is a promising strategy for developing more effective GBM therapies.

Purpose of the Study:

  • To investigate the therapeutic potential of inhibiting GTPase dynamin 2 in glioblastoma.
  • To evaluate the effects of dynamin inhibitors on glioblastoma cell viability, GSC behavior, and tumor growth.

Main Methods:

  • Treatment of glioblastoma cell lines and patient-derived GSCs with dynamin inhibitors (Dynole 34-2, CyDyn 4-36).
  • Assessment of cell viability, GSC neurosphere formation, and migration in vitro.
  • Evaluation of orthotopic tumor growth in vivo.

Main Results:

  • Dynamin inhibition significantly reduced glioblastoma cell line viability.
  • Inhibitors suppressed GSC neurosphere formation and migration.
  • Treatment with CyDyn 4-36 led to reduced tumor growth in vivo.

Conclusions:

  • Dynamin 2 inhibition demonstrates efficacy against glioblastoma.
  • Targeting dynamin 2 represents a novel, stem cell-directed therapeutic approach for glioblastoma.
Keywords:
Cancer biologyCancer stem cellsDynaminGlioblastomaInvasion

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