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Obesity and chemotherapy administration: between empiric and mathematic method review
W Bouleftour1, B Mery1, E Chanal1
1a Département d'oncologie médicale , Institut de cancérologie Lucien Newirth , Saint Priest en Jarez , France.
Acta Oncologica (Stockholm, Sweden)
|March 26, 2019
Summary
Chemotherapy dosing for obese cancer patients remains challenging. Current practices of capping doses may negatively impact patient outcomes, and more research is needed to determine optimal dosing strategies.
Area of Science:
- Oncology
- Pharmacology
- Obesity Medicine
Background:
- Obesity is a significant risk factor for chronic diseases and cancer.
- Managing cancer in obese patients presents challenges due to altered drug pharmacokinetics.
- Current chemotherapy dosing often involves arbitrary dose capping or ideal weight adjustments.
Purpose of the Study:
- To review the correlation between body surface area (BSA) adjustments (capping vs. ideal weight) and outcomes in obese cancer patients receiving chemotherapy.
- To assess global toxicities and survival rates based on different chemotherapy dosing strategies in this population.
Main Methods:
- Literature review of studies on chemotherapy dosing in obese populations.
- Search conducted in the Medline database (via PubMed) for relevant literature reviews.
Main Results:
- Limited evidence suggests full weight dosing may increase global toxicities in a single study.
- Some studies indicate that dose limitation in obese patients might compromise quality of care and outcomes.
- A growing obese population necessitates re-evaluation of current dosing practices.
Conclusions:
- There is a significant lack of prospective studies on chemotherapy administration methods for obese patients.
- No prospective studies currently compare capping versus full weight dose chemotherapy in obese individuals.
- Further research is essential to establish evidence-based chemotherapy dosing guidelines for obese cancer patients.
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