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Epigenetic alterations in mesenchymal stem cells by osteosarcoma-derived extracellular vesicles

Bettina Mannerström1, Roman Kornilov1, Ahmed G Abu-Shahba1,2

  • 1a Department of Oral and Maxillofacial Diseases , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

Epigenetics
|March 26, 2019
PubMed
Summary

Osteosarcoma (OS) extracellular vesicles (EVs) epigenetically alter mesenchymal stem cells (MSCs), suggesting a key role for EVs in early OS development and potential therapeutic targets.

Keywords:
DNA methylationLINE-1 methylationOsteosarcomaextracellular vesiclesflow cytometrymesenchymal stem cellsosteogenesis

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