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Updated: Jan 27, 2026

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
Published on: October 13, 2023
MOG antibody-associated encephalomyelitis/encephalitis
Sara Salama1, Majid Khan2, Santiago Pardo3
1Department of Neurology, Johns Hopkins University, Baltimore, MD, USA/Department of Neurology, University of Alexandria, Alexandria, Egypt.
Abstract:
Myelin oligodendrocyte glycoprotein (MOG) antibody disease is a rare autoimmune disorder with antibodies against the MOG predominantly involving the optic nerve and spinal cord leading to vision loss and paralysis. When MOG antibody disease involves the brain, the phenotype is similar to acute disseminated encephalomyelitis (ADEM). In this review, we discuss MOG-positive cases presenting with encephalitis, encephalopathy, or ADEM-like presentation based on recently published series.
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