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Glucose Oxidase-Instructed Multimodal Synergistic Cancer Therapy

Lian-Hua Fu1,2, Chao Qi1, Yan-Ru Hu1

  • 1Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, International Cancer Center, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, 518060, China.

Advanced Materials (Deerfield Beach, Fla.)
|March 26, 2019
PubMed

Insights

Glucose oxidase (GOx) shows promise for cancer therapy by altering the tumor microenvironment. Combining GOx with other treatments enhances synergistic effects for multimodal cancer treatment strategies.

Area of Science:

  • Biochemistry
  • Nanomedicine
  • Cancer Therapy

Background:

  • Glucose oxidase (GOx) is biocompatible and biodegradable.
  • GOx catalyzes glucose oxidation, producing gluconic acid and hydrogen peroxide.
  • This process impacts the tumor microenvironment by reducing oxygen and increasing acidity.

Purpose of the Study:

  • To review studies on GOx-instructed multimodal synergistic cancer therapy.
  • To discuss the synergistic mechanisms of GOx-based therapies.
  • To highlight challenges and future prospects for GOx nanomedicines.

Main Methods:

  • Systematic review of representative studies.
  • Analysis of GOx-instructed multimodal synergistic cancer therapy.
  • Discussion of synergistic mechanisms and challenges.

Main Results:

  • GOx triggers tumor hypoxia, acidity, and oxidative stress.
  • These changes facilitate multimodal synergistic cancer therapy.
  • GOx-based nanomedicines offer potential for advanced cancer treatment.

Conclusions:

  • GOx is a promising agent for multimodal cancer therapy.
  • Further development of GOx-based nanomedicines is warranted.
  • GOx-instructed therapies represent a cutting-edge research area.
Keywords:
cancer treatmentglucose oxidasestarvation therapysynergistic therapy

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