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Updated: Jan 27, 2026
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Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
Published on: February 10, 2023
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Advances in prognostic markers for colorectal cancer.
Lili Duan1, Wanli Yang1, Xiaoqian Wang1
1a State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, and Xijing Hospital of Digestive Diseases , Air Force Military Medical University , Xi'an , China.
Expert Review of Molecular Diagnostics
|March 26, 2019
Summary
This review highlights molecular markers for predicting colorectal cancer (CRC) prognosis. Combining various biomarkers shows promise for clinical application, but requires further validation.
Area of Science:
- Oncology
- Molecular Biology
- Epidemiology
Background:
- Colorectal cancer (CRC) is a leading cause of cancer deaths globally.
- CRC often presents with advanced disease due to asymptomatic early stages, leading to high mortality rates.
- Prognostic prediction is crucial for effective CRC management.
Purpose of the Study:
- To review recent advances in genetic, epigenetic, and proteomic molecular markers for CRC prognosis.
- To introduce immune and microbial biomarkers relevant to CRC.
- To discuss the role of molecular pathological epidemiology (MPE) in prognostic biomarker development.
Main Methods:
- Literature review focusing on recent advancements in CRC prognostic biomarkers.
- Synthesis of information on genetic, epigenetic, proteomic, immune, and microbial markers.
- Discussion of molecular pathological epidemiology (MPE) principles.
Main Results:
- Numerous molecular targets have been identified as potential prognostic markers for CRC.
- Limitations exist for individual biomarkers, restricting clinical application.
- Emerging biomarkers include immune and microbial factors, alongside traditional molecular markers.
Conclusions:
- A combination of multiple biomarkers may offer improved prognostic accuracy for CRC.
- Further large-scale clinical trials are essential to validate these biomarkers.
- Molecular pathological epidemiology (MPE) provides a framework for integrated biomarker research.
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