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Disparities in Care: Do Children with Autism Spectrum Disorder Experience Differential Medication Receipt In The
Eron Friedlaender1, Heather Griffis2, Jennifer Faerber3,4
1Department of Pediatrics, Division of Emergency Medicine, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Insights
Children with autism spectrum disorder (ASD) received similar pain management as neurotypical peers for appendicitis and fractures. However, children with ASD had higher rates of complicated appendicitis, indicating potential healthcare access or evaluation challenges.
Area of Science:
- Pediatric Emergency Medicine
- Neurodevelopmental Disorders
- Pain Management
Background:
- Autism spectrum disorder (ASD) affects individuals' ability to communicate pain and discomfort.
- Understanding pain management in children with ASD is crucial for effective healthcare delivery.
- Appendicitis and long bone fractures are common conditions requiring timely diagnosis and analgesia.
Purpose of the Study:
- To compare analgesia administration in neurotypical (NT) children and those with ASD presenting with appendicitis or long bone fractures in the emergency department (ED).
- To investigate differences in complicated appendicitis rates between children with ASD and NT children as a proxy for diagnostic delays.
Main Methods:
- Retrospective cohort study utilizing the Pediatric Health Information System database (2004-2015).
- Matched analysis of children aged 6-18 years with ASD and NT controls diagnosed with appendicitis or long bone fractures.
- Logistic regression and coarsened exact matching to assess medication receipt; pre-matching comparison for complicated appendicitis rates.
Main Results:
- No significant difference in the receipt of opioid or nonsteroidal anti-inflammatory drugs between children with ASD and NT controls.
- Children with ASD showed significantly higher rates of complicated appendicitis compared to NT controls (37.1% vs 29.9%, p < 0.001).
Conclusions:
- Analgesia administration was comparable between children with ASD and NT peers.
- Increased rates of complicated appendicitis in children with ASD suggest potential barriers in healthcare access or evaluation difficulties.
Objective:
The primary objective of this study was to describe analgesia administration between neurotypical (NT) individuals and those with autism spectrum disorder (ASD) diagnosed with appendicitis or long bone fractures in the emergency department (ED). A secondary objective was to compare the rates of complicated appendicitis as a proxy for delayed diagnosis between the groups.
Methods:
This is a retrospective cohort study using the Pediatric Health Information System database. Study participants were children aged 6 to 18 years with ASD and with an ED visit for appendicitis or fracture between 2004 and 2015 who were matched to demographically similar NT children. Children with a developmental disorder and/or complex chronic condition were excluded. Coarsened exact matching and logistic regression were used to investigate the association between ASD status and opioid and non-opioid medication receipt. Comparison of the rates of complicated appendicitis in children with ASD and NT children was conducted before matching.
Results:
From 2004 to 2015, 126,412 children with appendicitis and 392,151 children with long bone fractures were identified. Of these, 889 children had a diagnosis of ASD and were matched to 35,672 NT controls with appendicitis. In addition, 2117 children with ASD were matched to 200,635 NT controls with long bone fractures. Receipt of opioids or nonsteroidal anti-inflammatory drugs was not found to be significantly different between the 2 groups. However, a larger proportion of children with ASD presented with complicated appendicitis compared with NT controls (37.1% vs 29.9%, respectively; p < 0.001).
Conclusion:
Receipt of analgesia did not differ significantly between populations of ASD and NT peers. Children with ASD have increased rates of complex appendicitis, possibly suggesting limited access to care or provider difficulty in evaluating this patient population.
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