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Updated: Jan 27, 2026

Self-reporting Scaffolds for 3-Dimensional Cell Culture
Published on: November 7, 2013
Organocatalytic, Enantioselective, Polarity-Matched Ring-Reorganization Domino Sequence Based on the 3-Oxindole
Ji-Wei Ren1, Lan Zheng1, Zhi-Peng Ye1
1College of Chemistry and Chemical Engineering , Central South University , Changsha , Hunan 410083 , P. R. China.
Abstract:
A one-pot squaramide-catalyzed enantioselective ring-reorganization domino sequence (Michael addition/intramolecular ring-opening/lactamization) of 3-hydroxyoxindole and methyleneindolinone, which can be readily derived from 3-oxindole, has been established in this work. As a result, novel polycyclic quinolinone-spirooxindoles bearing three contiguous chiral centers were efficiently and step-economically assembled under mild conditions in high yields (up to 97%) with excellent enantioselectivities (up to >99% ee) and moderate to good diastereoselectivities (up to >95:5 dr).
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