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Related Experiment Videos

Local disodium cromoglycate is ineffective in ulcerative proctosigmoiditis.

N Hovdenak, L Halvorsen, K Nordgård

    Acta Medica Scandinavica
    |January 1, 1986
    PubMed
    Summary

    Disodium cromoglycate (DSCG) enemas did not improve ulcerative proctosigmoiditis symptoms or inflammation in a double-blind study. This study found no significant differences between DSCG and placebo for inflammatory bowel disease patients.

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    Area of Science:

    • Gastroenterology
    • Clinical Pharmacology

    Background:

    • Conflicting evidence exists regarding the efficacy of disodium cromoglycate (DSCG) for inflammatory bowel disease.
    • Previous studies have yielded varied results with oral and rectal administration of DSCG.

    Purpose of the Study:

    • To evaluate the efficacy of rectal disodium cromoglycate (DSCG) in treating active ulcerative proctosigmoiditis.
    • To compare DSCG enemas against a placebo in patients with ulcerative proctosigmoiditis.

    Main Methods:

    • A double-blind, placebo-controlled study involving 43 patients with active ulcerative proctosigmoiditis.
    • Patients received either 600 mg DSCG rectally as enemas or a placebo for eight weeks.
    • Clinical assessments, endoscopy, laboratory tests, biopsies, and diary cards were used for evaluation.

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    Main Results:

    • No statistically significant differences were observed between the DSCG and placebo groups in bowel frequency, rectal bleeding, or general well-being.
    • Abdominal pain, disease severity, and extent showed no significant improvement with DSCG treatment.
    • Histologic parameters and reported side-effects did not differ significantly between the groups.

    Conclusions:

    • Rectal administration of disodium cromoglycate (DSCG) did not demonstrate efficacy in improving symptoms or inflammatory changes in ulcerative proctosigmoiditis.
    • DSCG enemas were found to be ineffective for this patient population.
    • The study suggests that DSCG is not a beneficial treatment for active ulcerative proctosigmoiditis.