Related Experiment Video
Updated: Jan 27, 2026
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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
18.5K
Default mode network deactivation in pediatric temporal lobe epilepsy: Relationship to a working memory task and
Temitayo O Oyegbile1, John W VanMeter1, Gholam K Motamedi1
1Georgetown University Medical Center, Washington, DC, United States of America.
Epilepsy & Behavior : E&B
|March 26, 2019
Summary
Children with temporal lobe epilepsy show reduced default mode network deactivation during working memory tasks. These brain network alterations correlate with executive dysfunction, impacting cognitive performance.
Area of Science:
- Neuroscience
- Pediatric Neurology
- Cognitive Neuroscience
Background:
- Children with temporal lobe epilepsy (TLE) often experience executive dysfunction.
- Limited research exists on the specific functional network alterations linked to this dysfunction in pediatric TLE.
- Working memory deficits are a key aspect of executive dysfunction.
Purpose of the Study:
- To investigate working memory deficits in children with TLE.
- To assess default mode network (DMN) deactivation using functional Magnetic Resonance Imaging (fMRI).
- To explore the relationship between DMN deactivation, fMRI findings, and neuropsychological test performance.
Main Methods:
- fMRI scans were performed on 15 children with TLE and 15 healthy controls (ages 8-16).
- Participants completed the N-back task to evaluate DMN deactivation.
- Executive function was assessed using the Delis-Kaplan Executive Function System (D-KEFS) tests.
Main Results:
- Children with TLE demonstrated significantly less DMN deactivation, particularly in the precuneus/posterior cingulate cortex, compared to controls.
- These DMN alterations were significantly correlated with N-back task performance and D-KEFS results.
- Functional network alterations were observed in extratemporal brain regions.
Conclusions:
- Executive dysfunction in children with TLE is associated with alterations in the DMN.
- Reduced deactivation in specific functional networks may contribute to cognitive impairment in pediatric TLE.
- Findings highlight the presence of extratemporal network abnormalities in children with TLE.
Keywords:
Default mode networkExecutive dysfunctionN-back taskNeuropsychological testingPediatricTemporal lobe epilepsyMore Related Videos
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