Related Experiment Video

Updated: Jan 27, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
09:49

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Published on: July 5, 2019

10.0K

CCDC6, a gene product in fusion with different protoncogenes, as a potential chemotherapeutic target

Aishwarya Laxmi1,1, Pawan Gupta2,3,1, Jeena Gupta1

  • 1School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, India.

Cancer Biomarkers : Section a of Disease Markers
|March 26, 2019
PubMed

Insights

CCDC6 is a tumor suppressor gene involved in DNA repair. This review explores CCDC6 fusions with proto-oncogenes and the potential of phytochemicals to modulate its activity for cancer therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer arises from abnormal cell growth due to genetic alterations, often involving faulty DNA repair mechanisms.
  • CCDC6 functions as a tumor suppressor gene, crucial in DNA repair and apoptosis.
  • CCDC6 was initially identified in thyroid tumors with chromosomal translocations involving the RET proto-oncogene, leading to fusion genes that impair its function.

Purpose of the Study:

  • To review and characterize CCDC6 fusions with various proto-oncogenes.
  • To explore the potential role of natural phytochemicals in modulating CCDC6 activity.
  • To assess the therapeutic implications of targeting CCDC6 fusions and phytochemical interactions in cancer.

Main Methods:

  • Literature review of published studies on CCDC6.
  • Analysis of CCDC6 gene fusions with different proto-oncogenes.
  • Investigation into the effects of natural phytochemicals on CCDC6 function.

Main Results:

  • CCDC6 forms fusion genes with multiple proto-oncogenes, such as RET, which can disrupt its tumor suppressor activity.
  • CCDC6 is a pro-apoptotic phosphoprotein and an ATM substrate, responding to genotoxic stress.
  • Natural phytochemicals show potential in altering CCDC6 activity.

Conclusions:

  • Understanding CCDC6 fusions is critical for cancer research.
  • Phytochemicals may offer a novel therapeutic strategy by modulating CCDC6 activity.
  • Further research into CCDC6 and phytochemical interactions could benefit cancer patients.
Keywords:
CCDC6DNA repaircancerchimeric proteinproto-oncogenes

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