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Updated: Jan 27, 2026
10:38
Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos
Published on: September 9, 2015
10.9K
Mycobacterium abscessus: Environmental Bacterium Turned Clinical Nightmare
Rose C Lopeman1, James Harrison2, Maya Desai3
1School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK. lopemarc@aston.ac.uk.
Microorganisms
|March 27, 2019
Summary
Nontuberculous mycobacteria (NTM), particularly Mycobacterium abscessus, cause opportunistic infections. This review examines M. abscessus, its treatment, drug resistance, and the urgent need for novel therapies and improved testing methods.
Area of Science:
- Microbiology
- Infectious Diseases
- Medical Mycology
Background:
- Mycobacteria encompass over 100 species, with most being nontuberculous mycobacteria (NTM).
- Unlike tuberculosis (TB) and leprosy, NTM infections are acquired from the environment.
- Mycobacterium abscessus (M. abs) is an emerging NTM causing pulmonary and skin infections.
Purpose of the Study:
- To review the understanding and treatment of Mycobacterium abscessus infections.
- To examine drug resistance mechanisms and novel treatment strategies for M. abs.
- To highlight the need for effective treatments and improved efficacy testing for M. abs.
Main Methods:
- Literature review of Mycobacterium abscessus.
- Analysis of current treatment approaches for M. abs infections.
- Examination of drug resistance and emerging therapies.
Main Results:
- Mycobacterium abscessus is a significant opportunistic pathogen, especially in patients with lung disorders.
- Drug resistance is a major challenge in treating M. abs infections.
- Novel treatments and improved diagnostic/testing methods are under development.
Conclusions:
- There is an urgent need for new and effective treatments against Mycobacterium abscessus.
- Further research into drug resistance mechanisms and novel therapies is crucial.
- Improved in vivo methods for testing treatment efficacy are required.
Keywords:
Mycobacterium abscessusantimicrobial drug discoverycystic fibrosisnon-tuberculous mycobacteriaMore Related Videos
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