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Updated: Jan 27, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking
Published on: January 28, 2019
AMPA Receptor Auxiliary Proteins of the CKAMP Family
1Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany. engelhardt@uni-mainz.de.
Abstract:
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are assembled of four core subunits and several additional interacting proteins. Cystine-knot AMPA receptor-modulating proteins (CKAMPs) constitute a family of four proteins that influence the trafficking, subcellular localization and function of AMPA receptors. The four CKAMP family members CKAMP39/shisa8, CKAMP44/shisa9, CKAMP52/shisa6 and CKAMP59/shisa7 differ in their expression profile and their modulatory influence on AMPA receptor function. In this review, I report about recent findings on the differential roles of CKAMP family members.
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