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Related Experiment Video

Updated: Jan 27, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Psoriasis Pathogenesis and Treatment.

Adriana Rendon1, Knut Schäkel2

  • 1Department of Dermatology, Heidelberg University, 69120 Heidelberg, Germany. RuthAdriana.RendonMedina@med.uni-heidelberg.de.

International Journal of Molecular Sciences
|March 27, 2019
PubMed
Summary
This summary is machine-generated.

Psoriasis research has revealed key inflammatory pathways, particularly the IL-23/Th17 axis, leading to targeted therapies. This review details disease mechanisms and treatment options for chronic inflammatory skin conditions.

Keywords:
chronic skin diseaseinflammationpsoriasis

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Area of Science:

  • Dermatology and immunology, focusing on skin biology and chronic inflammatory diseases.

Background:

  • Psoriasis pathogenesis research has significantly advanced understanding of skin biology.
  • Recent breakthroughs illuminate the IL-23/Th17 axis in chronic inflammatory diseases.

Purpose of the Study:

  • To review the mechanisms of psoriasis initiation and development.
  • To discuss therapeutic options derived from understanding psoriatic inflammatory pathways.

Main Methods:

  • Review of inflammatory pathways and key cell types in psoriatic inflammation.
  • Examination of genetic, epigenetic, and skin flora interactions in psoriasis pathophysiology.
  • Comprehensive analysis of established and novel targeted therapies.

Main Results:

  • Elucidation of the dominant IL-23/Th17 axis in psoriasis pathogenesis.
  • Identification of key cellular and molecular mechanisms driving psoriatic inflammation.
  • Development of targeted therapies based on mechanistic insights.

Conclusions:

  • Advances in understanding psoriasis pathogenesis have yielded effective targeted treatments.
  • The IL-23/Th17 pathway is central to psoriasis and other chronic inflammatory diseases.
  • Future research and therapeutic development continue to benefit from this knowledge.