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Updated: Jul 26, 2026

RNA Interference in Ticks
Published on: January 20, 2011
Functional RNA Structures in the 3'UTR of Tick-Borne, Insect-Specific and No-Known-Vector Flaviviruses
Roman Ochsenreiter1, Ivo L Hofacker2,3, Michael T Wolfinger4,5
1Department of Theoretical Chemistry, University of Vienna, Währingerstraße 17, 1090 Vienna, Austria. romanoch@tbi.univie.ac.at.
Abstract:
Untranslated regions (UTRs) of flaviviruses contain a large number of RNA structural elements involved in mediating the viral life cycle, including cyclisation, replication, and encapsidation. Here we report on a comparative genomics approach to characterize evolutionarily conserved RNAs in the 3 ' UTR of tick-borne, insect-specific and no-known-vector flaviviruses in silico. Our data support the wide distribution of previously experimentally characterized exoribonuclease resistant RNAs (xrRNAs) within tick-borne and no-known-vector flaviviruses and provide evidence for the existence of a cascade of duplicated RNA structures within insect-specific flaviviruses. On a broader scale, our findings indicate that viral 3 ' UTRs represent a flexible scaffold for evolution to come up with novel xrRNAs.
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