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Related Experiment Video

Updated: Jan 27, 2026

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

Macrophages as delivery vehicles for anticancer agents.

Steen J Madsen¹, Henry Hirschberg^1,2

¹Department of Health Physics & Diagnostic Sciences, University of Nevada, Las Vegas, NV 89154, USA.

Therapeutic Delivery

|March 27, 2019

Summary

Cell-based delivery using monocytes/macrophages shows promise for enhanced anticancer agent delivery, overcoming limitations of passive methods. While effective in preclinical studies, clinical translation requires further investigation.

Keywords:

chemotherapeutics gene therapy gliomas gold–silica nanoshells macrophages monocytes nanoparticles photochemical internalization photodynamic therapy photothermal therapy

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Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

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Area of Science:

Biomedical Engineering
Oncology
Cell Biology

Background:

Passive drug delivery (e.g., enhanced permeability and retention effect) often fails to reach adequate concentrations within tumors.
Cell-based delivery systems offer a potential solution to overcome passive delivery limitations.

Purpose of the Study:

To review the use of monocytes/macrophages as a cell-based delivery system for anticancer agents.
To evaluate the efficacy of this approach in preclinical settings and discuss its clinical potential.

Main Methods:

Review of literature on monocyte/macrophage-mediated delivery of nanoparticles, chemotherapeutics, and gene constructs.
Analysis of in vitro and animal studies demonstrating therapeutic efficacy.
Assessment of combination therapies, including phototherapy.

Main Results:

Monocytes/macrophages can be engineered to deliver various anticancer agents effectively.
Preclinical studies show efficacy for monotherapy and combination treatments.
Demonstrated potential in overcoming limitations of passive drug delivery strategies.

Conclusions:

Monocyte/macrophage-based delivery represents a promising strategy for cancer treatment.
Further research is needed to determine the clinical applicability of this approach.