Related Experiment Video
Updated: Jan 27, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
A proposal for a self-rated frailty index and status for patient-oriented research
Yi-Sheng Chao1, Danielle McGolrick1, Chao-Jung Wu2
1Canadian Agency for Drugs and Technologies in Health, Ottawa, Canada.
Objective:
Frailty indices are important predictors of major health outcomes, but mostly designed by and for researchers and specialists. Three of the most commonly used theory-based indices are composite measures that are subject to arbitrary assumptions and biases introduced due to data processing. A complicated index can be simplified with fewer items. The theory-based frailty indices are not optimal and neglect patients' perspectives. This study aims to compare different definitions of frailty and propose a self-rated measure of frailty index and status.
Results:
Frailty was defined differently by laypeople and researchers/clinicians. Patients' and laypeople's perspectives seemed neglected. Existing frailty indices had shortcomings related to the use of composite measures, assumptions of frailty theories, and the lack of novel information. To avoid these shortcomings, we suggested asking individuals "on a scale of 0 to 10, how frail do you think you are?" and "by answering yes or no, do you consider yourself to be frail?" to determine frailty on continuous and dichotomous scales respectively. However, there will be other issues emerging with these new measures, such as the need for feasibility and validity studies, as well as acceptability by researchers.
Related Concept Videos
Rate-Determining Steps
In a multistep reaction mechanism, one of the elementary steps progresses significantly slower than the others. This slowest step is called the rate-limiting step (or rate-determining step). A reaction cannot proceed faster than its slowest step, and hence, the rate-determining step limits the overall reaction rate.
The concept of rate-determining step can be understood from the analogy of a 4-lane freeway with a short-stretch of traffic-bottleneck caused due to...
Location and Orientation of the Heart
Measuring Reaction Rates
Temperature Dependence on Reaction Rate
Atoms, molecules, or ions must collide before they can react with each other. Atoms must be close together to form chemical bonds. This premise is the basis for a theory that explains many observations regarding chemical kinetics, including factors affecting reaction rates.
The collision theory is based on the postulates that (i) the reaction rate is proportional to the rate of reactant collisions, (ii) the reacting species collide in an orientation allowing contact between...
Marcia's Theory of Identity Status
Reaction Rate
The mathematical representation of the change in the concentration of reactants and products, over time, is the rate...

