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Updated: Jan 27, 2026

EEG Mu Rhythm in Typical and Atypical Development
Published on: April 9, 2014
[Atypical genital development and tumor risk]
Cécile Faure Conter1, Daniela Brindusa Gorduza2, Pierre-Yves Mure2
1Institut d'hématologie et d'oncologie pédiatrique, IHOPe, 69008 Lyon, France.
Abstract:
Atypical genital development (AGD), also called disorders of sex development are a set of miscellaneous pathologies who have in common a morphological and/or functional abnormality of the internal and/or external genital organs. The Chicago classification identifies 3 major groups based on karyotype, hormone balance and genetic studies. Some AGD predispose to the occurrence of tumors, mainly malignant germ cell tumors. The tumor risk depends on many factors: the type of AGD, the position of the gonad, the age of the patient, the phenotype, the function of the gonad and the presence of germ cells in the gonad. AGD with the highest tumor risk are those with gonadal dysgenesis, implying an incomplete differentiation of the bipotential gonad (dysplasia). Monitoring of patients with AGD and indication of prophylactic gonadectomies should be individualized according to tumor risk.
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