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Fetal stem cell transplantation and gene therapy
Rachel Sagar1, Cecilia Götherström2, Anna L David3
1Institute for Women's Health, University College London, London, UK.
Best Practice & Research. Clinical Obstetrics & Gynaecology
|March 27, 2019
Summary
Fetal stem cell and gene therapy offer promising treatments but face significant safety, ethical, and methodological challenges. Careful monitoring and interdisciplinary collaboration are crucial for successful clinical implementation of these prenatal therapies.
Area of Science:
- Regenerative Medicine
- Medical Genetics
- Prenatal Medicine
Background:
- Fetal stem cell therapy and gene therapy represent innovative approaches to treating congenital diseases.
- Understanding past experiences and ongoing human studies is essential for advancing these fields.
- Methodological, safety, and ethical considerations are paramount for clinical translation.
Purpose of the Study:
- To summarize current knowledge on fetal stem cell and gene therapy.
- To review past, ongoing, and planned human studies.
- To discuss challenges and requirements for clinical implementation.
Main Methods:
- Literature review and synthesis of existing data on fetal stem cell and gene therapy.
- Analysis of methodological challenges, safety protocols, and ethical considerations.
- Emphasis on the importance of interdisciplinary collaboration and patient monitoring.
Main Results:
- Fetal stem cell and gene therapies are promising but require specialized approaches.
- Significant challenges exist in methodology, safety, and ethical aspects.
- Careful monitoring and extended follow-up of mother and child are critical.
Conclusions:
- Prenatal stem cell and gene therapies necessitate stringent safety and ethical evaluations.
- Successful clinical introduction requires addressing methodological hurdles and ensuring comprehensive monitoring.
- Interdisciplinary collaboration is vital for advancing experimental fetal therapies.
Keywords:
A-thalassemiaFetal therapyGene therapyHematopoetic stem cellMesenchymal stem cellsOsteogenesis imperfectaMore Related Videos
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