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Evaluation of a Temporal Association between Vaccination and Subdural Hematoma in Infants

Juliette Fleury1, Pauline Scherdel2, Eric Frampas3

  • 1Unité d'accueil des enfants en danger, University Hospital of Nantes, Nantes, France; Pediatric and Emergency Department, University Hospital of Nantes, Nantes, France.

The Journal of Pediatrics
|March 27, 2019
PubMed

Insights

This study found no link between infant vaccination and subdural hematoma. Subdural hematoma remains a critical indicator of abusive head trauma in children.

Area of Science:

  • Pediatrics
  • Neurology
  • Public Health

Background:

  • Subdural hematoma is a key indicator of abusive head trauma in infants.
  • Investigating potential triggers like vaccination is crucial for understanding infant injuries.

Purpose of the Study:

  • To determine if there is a temporal association between infant vaccination and the occurrence of subdural hematoma.
  • To assess if vaccination is a risk factor for subdural hematoma, a marker of abusive head trauma.

Main Methods:

  • A nested case-control study was conducted using data from a prospective population-based survey in France (2015-2017).
  • Infants aged 11-52 weeks undergoing initial cerebral imaging were included. Cases with subdural hematoma (and suspected abusive head trauma) were compared to controls without subdural hematoma.
  • Vaccination status was meticulously recorded from health booklets and compared between cases and controls, matched for age.

Main Results:

  • The study analyzed 28 infants with subdural hematoma (22 with abusive head trauma) and 62 controls.
  • No significant temporal association was found between vaccination and subdural hematoma diagnosis.
  • Rates of vaccination and timing relative to imaging did not differ significantly between cases and controls.

Conclusions:

  • The findings do not support a link between vaccination and subdural hematoma in infants.
  • Subdural hematoma should continue to be recognized as a significant sign of abusive head trauma and child abuse.
  • Further research may explore other potential factors contributing to subdural hematoma in infants.
Abstract

Keywords:
abusive head traumaepidemiologicimmunizationintracranial hemorrhagesubdural hematoma

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