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Relation of IGF-1 and IGFBP-3 with prevalent and incident atrial fibrillation in a population-based study

Mathias Busch1, Anne Krüger1, Stefan Gross1

  • 1Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.

Heart Rhythm
|March 27, 2019
PubMed

Insights

Low levels of Insulin-like Growth Factor 1 (IGF-1) and its binding protein IGFBP-3 are linked to a higher prevalence of atrial fibrillation (AF). This association also appears to impact incident AF cases.

Area of Science:

  • Endocrinology
  • Cardiology
  • Epidemiology

Background:

  • Insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) are implicated in cardiovascular diseases.
  • The specific relationship between IGF-1/IGFBP-3 and atrial fibrillation (AF) remains largely uncharacterized.

Purpose of the Study:

  • To investigate the association between IGF-1 and IGFBP-3 levels and the prevalence and incidence of AF.
  • To analyze these associations within a large, population-based cohort.

Main Methods:

  • Utilized data from the Study of Health in Pomerania (SHIP).
  • Assessed prevalent AF at baseline and incident AF during a mean follow-up of 5.2 years.
  • Measured serum IGF-1 and IGFBP-3 levels, alongside electrocardiographic assessments.

Main Results:

  • Lower IGF-1 and IGF-1/IGFBP-3 ratios were observed in participants with prevalent AF.
  • A low IGF-1/IGFBP-3 ratio was significantly associated with prevalent AF (OR 0.67; P = .021).
  • Lower IGF-1 levels, but not IGF-1/IGFBP-3 ratios, were associated with incident AF.

Conclusions:

  • Low IGF-1/IGFBP-3 ratios are linked to a higher prevalence of atrial fibrillation.
  • A similar association may exist for incident AF, warranting further investigation.
Abstract

Keywords:
Atrial fibrillationCardiovascular diseaseIGFBP-3Insulin-like growth factor 1Population-based studyRisk factor

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