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When a wave travels from one medium to another, it gets reflected at the boundary of the second medium. A common example of this is when a person yells at a distance from a cliff and hears the echo of their voice. The sound waves (longitudinal waves) traveling in the air are reflected from the bounding cliff. Similarly, flipping one end of a string whose other end is tied to a wall causes a pulse (transverse wave) to travel through the string, which gets reflected upon reaching the wall. In...
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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D-Serine reflects kidney function and diseases.

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D-serine, a specific amino acid, shows promise as a biomarker for kidney disease. Its blood and urine levels accurately reflect kidney function and aid in early chronic kidney disease (CKD) detection.

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Area of Science:

  • Biochemistry
  • Nephrology
  • Biomarker Discovery

Background:

  • Chronic kidney disease (CKD) presents a global health challenge due to difficulties in early detection and functional assessment.
  • D-amino acids, previously undetected enantiomers of L-amino acids, are emerging as significant biomarkers.
  • Current CKD management is hampered by limitations in estimating kidney function and diagnosing the disease early.

Purpose of the Study:

  • To investigate the role of D-serine intra-body dynamics as a potential biomarker for kidney function and disease.
  • To explore the chiral selectivity of amino acid reabsorption and excretion by the kidney.
  • To assess the efficacy of D-serine levels in distinguishing CKD from non-CKD states.

Main Methods:

  • Correlation analysis of blood D-serine levels with glomerular filtration rate (GFR).
  • Evaluation of D-serine levels' independence from clinical factors like body size.
  • Analysis of urinary D-serine dynamics in relation to CKD presence.
  • Assessment of kidney's chiral selectivity in amino acid handling.

Main Results:

  • Blood D-serine levels strongly correlated with glomerular filtration ratio, a key indicator of kidney function.
  • D-serine reabsorption by the kidney demonstrated sensitivity to CKD.
  • Combined analysis of blood and urinary D-serine effectively differentiated CKD patients from healthy individuals.
  • D-serine levels showed relative stability against confounding clinical factors such as body size.

Conclusions:

  • Intra-body dynamics of D-serine serve as a reliable indicator of kidney function and disease.
  • D-serine exhibits chiral selectivity in renal handling, making it sensitive to CKD.
  • D-serine holds potential as a vital biomarker for precise kidney function assessment and early CKD diagnosis, potentially aiding in disease prevention.