Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Energy to Drive Translocation01:37

Energy to Drive Translocation

2.7K
Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
Generally, polypeptides are unfolded by two distinct...
2.7K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

6.4K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
6.4K
Dynamic Equilibrium02:20

Dynamic Equilibrium

62.1K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
62.1K
Drive-Reduction Theory: Push Theory of Motivation01:27

Drive-Reduction Theory: Push Theory of Motivation

1.2K
Clark Hull's drive-reduction theory, introduced in the 1940s and 1950s and often termed the "push theory" of motivation, provides a framework for understanding how biological and learned drives influence behavior. Hull suggested that motivation originates from the need to alleviate physiological tension caused by unmet biological necessities. The theory proposes that when a basic need, such as hunger or sleep, goes unfulfilled, it creates an internal imbalance. This imbalance, or...
1.2K
Equation of Rotational Dynamics01:08

Equation of Rotational Dynamics

14.7K
Angular variables are introduced in rotational dynamics. Comparing the definitions of angular variables with the definitions of linear kinematic variables, it is seen that there is a mapping of the linear variables to the rotational ones. Linear displacement, velocity, and acceleration have their equivalents in rotational motion, which are angular displacement, angular velocity, and angular acceleration. Similar to the rotational variables, a mapping exists from Newton's second law of motion...
14.7K
Fermi Level Dynamics01:12

Fermi Level Dynamics

692
The vacuum level denotes the energy threshold required for an electron to escape from a material surface. It is usually positioned above the conduction band of a semiconductor and acts as a benchmark for comparing electron energies within various materials.
Electron affinity in semiconductors refers to the energy gap between the minimum of its conduction band and the vacuum level and it is a critical parameter in determining how easily a semiconductor can accept additional electrons.
The work...
692

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PfApiAT2 is a proline transporter essential for the transmission of Plasmodium falciparum by the mosquito vector.

Nature communications·2026
Same author

Hidden hematological, biochemical and immune costs of asymptomatic malaria infections in semi-wild chimpanzees.

PLoS pathogens·2026
Same author

Malaria Epidemiological Characteristics in Urban and Suburban Areas of Bamako, Mali.

Journal of parasitology research·2026
Same author

Anopheles mosquitoes exposed to long-acting antimalarials via drug-supplemented bloodmeal absorb drug but do not suffer fitness costs.

The Journal of infectious diseases·2026
Same author

Complex non-<i>falciparum</i> transmission and widespread insecticide resistance in Penka-Michel, a hyperendemic malaria focus of the Cameroon highlands.

Research square·2026
Same author

Knowledge, attitudes and practices towards malaria in a peri-urban Cameroonian village: Persistent silent transmission despite satisfactory awareness.

PloS one·2026

Related Experiment Video

Updated: Jan 27, 2026

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination
14:10

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination

Published on: July 4, 2007

18.4K

Mosquito microevolution drives Plasmodium falciparum dynamics.

Markus Gildenhard1, Evans K Rono1, Assetou Diarra2

  • 1Max Planck Institute for Infection Biology, Berlin, Germany.

Nature Microbiology
|March 27, 2019
PubMed
Summary

Changes in mosquito genetics, not just numbers, drive malaria parasite spread in Africa. Understanding mosquito microevolution is key for effective malaria control strategies targeting specific vector species.

More Related Videos

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors
05:28

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

3.6K
Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding
09:23

Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding

Published on: July 3, 2020

8.4K

Related Experiment Videos

Last Updated: Jan 27, 2026

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination
14:10

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination

Published on: July 4, 2007

18.4K
Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors
05:28

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

3.6K
Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding
09:23

Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding

Published on: July 3, 2020

8.4K

Area of Science:

  • Vector biology
  • Malaria transmission dynamics
  • Population genetics

Background:

  • Malaria remains a significant cause of child mortality in Africa, transmitted by Anopheles mosquitoes.
  • The ecology and evolution of Anopheles vectors are linked to Plasmodium parasite fitness.
  • The impact of vector population genetic structure on malaria transmission is not well understood.

Purpose of the Study:

  • To investigate whether the genetic structure of African malaria vector populations influences Plasmodium parasite abundance and transmission.
  • To differentiate between generalist and specialist Anopheles mosquito populations evolving along ecological boundaries.
  • To identify which mosquito species contribute most significantly to Plasmodium abundance.

Main Methods:

  • Partitioning African malaria vectors into generalist and specialist groups based on ecological evolution.
  • Utilizing Granger causality tests on time-series data from two rainy seasons in Mali.
  • Analyzing the relationship between mosquito microevolution and Plasmodium dynamics.

Main Results:

  • Mosquito microevolution, characterized by shifts in genetic structure over short ecological timescales, was identified as the primary driver of Plasmodium dynamics.
  • Vector abundance, infection prevalence, temperature, and rainfall showed limited predictive value for Plasmodium dynamics.
  • Specific mosquito species were identified as significant contributors to Plasmodium abundance.

Conclusions:

  • Mosquito microevolution plays a critical role in driving malaria transmission dynamics in natural settings.
  • Time-series analyses are powerful tools for understanding vector biology and disease transmission.
  • Targeting vector control strategies towards specific mosquito species that drive malaria dynamics is crucial for effective local interventions.