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Published on: June 4, 2020
Clot Mayhem: A Case of May-Thurner Syndrome
Asrar Ahmad1, Muhammad A Zain2, Ammar A Ashfaq1
1Internal Medicine, Abington Memorial Hospital, Abington, USA.
Insights
May-Thurner syndrome (MTS) can cause recurrent deep venous thrombosis (DVT). Successful treatment involved venous stenting for iliac vein compression, resolving the patient's severe DVT symptoms.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Hematology
Background:
- May-Thurner syndrome (MTS), or iliac vein compression syndrome, involves anatomical compression of the left common iliac vein by the right common iliac artery.
- This compression can lead to blood stasis and predispose individuals to deep venous thrombosis (DVT) in the iliofemoral system.
Observation:
- A patient with a history of DVT and therapeutic anticoagulation presented with recurrent left leg swelling and pain.
- Initial treatments including anticoagulation, thrombolysis, and mechanical thrombectomy were unsuccessful in resolving the massive DVT.
Findings:
- Venous Doppler ultrasound confirmed MTS with significant left common iliac vein compression.
- The patient's DVT resolved after successful venous stent placement in the iliac vein.
Implications:
- Venous stenting is an effective treatment for May-Thurner syndrome-associated DVT.
- This case highlights the importance of diagnosing MTS in recurrent or refractory DVT cases.
- Combined interventional and medical management can achieve successful outcomes in complex DVT cases.
Abstract:
May-Thurner syndrome (MTS), also known as the iliac vein compression syndrome, is an anatomic anomaly in which the compression of the left common iliac vein by an overlying right common iliac artery leads to blood stasis, which predisposes to deep venous thrombosis (DVT) in the iliofemoral venous system. We present a case of a female with a history of DVT and currently on warfarin with a therapeutic international normalized ratio (INR), admitted with left leg swelling, redness, and intractable pain. Venous Doppler scan confirmed a massive DVT from the level of the left common femoral vein to the popliteal vein. The clot recurred after an unsuccessful trial of argatroban, in-line pharmacokinetic thrombolysis with local catheter-based alteplase infusion, and interventional radiology (IR)-guided mechanical thrombectomy. Subsequently, the patient was diagnosed as MTS with overlying left common iliac vein compression, as evident on venous Doppler ultrasound. She was managed successfully by venous stent placement and ongoing systemic anticoagulation with fondaparinux.
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