Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

6.9K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.9K
Autoimmune Disorders01:29

Autoimmune Disorders

1.6K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.6K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.1K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.1K
Cable Subjected to Its Own Weight01:13

Cable Subjected to Its Own Weight

792
Overhead power transmission lines rely on cables to carry electricity across large distances. To ensure the stability and functionality of these lines, it is crucial to understand the shape and tension experienced by the cables under the influence of their weight.
A generalized loading function is employed to analyze a cable subjected to its own weight. This function considers the force acting along the cable's arc length rather than its projected length, providing a more accurate...
792
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

7.4K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.4K
Assessment of the Gastrointestinal System I: Subjective Data01:17

Assessment of the Gastrointestinal System I: Subjective Data

642
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
642

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering miRNA-223 nanocomplexes via bioorthogonal self-assembly for precision therapy of intervertebral disc degeneration.

Biomaterials·2026
Same author

Chalcogen-bonding-mediated chiral recognition and enantioenrichment of organoselenocyanates.

Chemical science·2026
Same author

Semiparametric Joint Modeling for Survival Analysis with Longitudinal Covariates.

Journal of the American Statistical Association·2026
Same author

Utilization of Robust Zr-Based Metal-Organic Framework for Efficient N<sub>2</sub>/H<sub>2</sub> Separation.

Materials (Basel, Switzerland)·2026
Same author

The clinical role of lncRNA PRKG1-AS1 in lumbar disc degeneration and its mechanism in regulating inflammation and ferroptosis via miR-218-5p.

Journal of orthopaedic surgery and research·2026
Same author

Improving Ambient-Temperature Hydrogen Storage of Ni<sub>2</sub>(m-dobdc) via Anchoring Site and Distribution of Li in Nanopores.

Inorganic chemistry·2026
Same journal

A State of the Art Review on the Recalcitrant Candidiasis as a Clue of Inborn Errors of Immunity in Newborns.

Journal of immunology research·2026
Same journal

The Relationship Between CCN3 and Rheumatoid Arthritis and Its Potential Therapeutic Value.

Journal of immunology research·2026
Same journal

Novel Biomarker for Antimitochondrial Antibodies in Systemic Sclerosis Patients.

Journal of immunology research·2026
Same journal

Anti-MAG Polyneuropathy: Characterization of the Monoclonal Gammopathy and Clonal B-Cell Population.

Journal of immunology research·2026
Same journal

Immunophenotypic Profiling of Lymphocyte Subsets in Children and Adolescents With Acute Lymphoblastic Leukaemia: Immune Dysregulation Before and After Remission.

Journal of immunology research·2026
Same journal

PD-L1 Expression in Acute Myeloid Leukemia Cells: Associations With Cell Metabolism.

Journal of immunology research·2026
See all related articles

Related Experiment Video

Updated: Jan 27, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K

Exploring Systemic Autoimmunity in Thyroid Disease Subjects.

Thushani Siriwardhane1, Karthik Krishna2, Vinodh Ranganathan2

  • 1Vibrant America LLC, San Carlos, CA, USA.

Journal of Immunology Research
|March 27, 2019
PubMed
Summary
This summary is machine-generated.

Autoimmune thyroid disease often coexists with systemic autoimmune diseases like ANA and anti-ENA. Anti-TPO antibodies appear earlier, suggesting monitoring for early systemic autoimmune disease detection.

More Related Videos

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

3.0K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.2K

Related Experiment Videos

Last Updated: Jan 27, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K
A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

3.0K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.2K

Area of Science:

  • Immunology
  • Endocrinology
  • Rheumatology

Background:

  • Individuals with one autoimmune condition face increased risk for subsequent autoimmune diseases.
  • The sequence of autoimmune disease development and associated autoantibodies remains unclear.
  • This study investigates the co-occurrence and timing of autoantibodies in thyroid and systemic autoimmune diseases.

Purpose of the Study:

  • To explore the association between thyroid autoantibodies and systemic autoimmune antibodies (ANA, ENA).
  • To determine the sequential occurrence of autoantibodies in individuals with thyroid-related symptoms.
  • To assess the prevalence of ANA and anti-ENA in patients with autoimmune thyroid disease.

Main Methods:

  • Analysis of thyroid markers (TSH, FT4, anti-TPO, anti-Tg) and autoimmune panels (ANA, ENA) in 14,825 subjects.
  • Retrospective assessment of ANA and anti-ENA prevalence in thyroid-positive cohorts.
  • A 2-year follow-up study to track the appearance order of autoimmune markers.

Main Results:

  • High prevalence of ANA (17.7–20.5%) and anti-ENA (26.9–28.4%) observed in subjects with autoimmune thyroid disease.
  • Prevalence of anti-ENA was notably higher than ANA in these cohorts.
  • Anti-thyroid peroxidase (anti-TPO) antibodies appeared significantly earlier than ANA and anti-ENA (average 253 and 227 days prior, respectively).

Conclusions:

  • Autoimmune thyroid disease frequently coexists with systemic autoimmune diseases, indicated by high ANA and anti-ENA prevalence.
  • Anti-thyroid peroxidase (anti-TPO) antibodies precede the development of ANA and anti-ENA.
  • Regular monitoring for ANA and anti-ENA in anti-TPO positive individuals can aid in early systemic autoimmune disease detection.