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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

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The incidence of mild cognitive impairment: A systematic review and data synthesis

Cai Gillis1, Fariba Mirzaei2, Michele Potashman2

  • 1Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
|March 27, 2019
PubMed
Abstract

Insights

Estimates for mild cognitive impairment (MCI) incidence vary. This study provides age-specific rates, finding higher incidence in older adults, but significant heterogeneity persists across studies.

Area of Science:

  • Gerontology
  • Epidemiology
  • Neurology

Background:

  • Estimates for mild cognitive impairment (MCI) incidence show wide variability.
  • Understanding contemporary, age-specific MCI incidence is crucial.
  • Sources of heterogeneity in MCI incidence require examination.

Purpose of the Study:

  • To determine contemporary age-specific incidence rates for mild cognitive impairment (MCI).
  • To investigate and identify sources of heterogeneity in MCI incidence estimates.

Main Methods:

  • Systematic review of population-based studies from the Americas, Europe, and Australia.
  • Restrictive inclusion criteria were applied to minimize heterogeneity.
  • Quantitative meta-analyses and qualitative descriptive analyses synthesized incidence data for MCI and its subtypes across 5-year age categories.

Main Results:

  • Meta-analysis revealed MCI incidence per 1000 person-years: 22.5 (75-79y), 40.9 (80-84y), and 60.1 (85+y).
  • Considerable heterogeneity (I² statistic) persisted despite stringent inclusion criteria.
  • Findings were consistent across meta-analysis, descriptive statistics, and qualitative review.

Conclusions:

  • Heterogeneity in mild cognitive impairment incidence estimates remains evident across age groups and populations.
  • Discrepancies in populations studied and methodologies likely contribute to observed heterogeneity.
  • Reported incidence rate ranges are essential alongside summary point estimates for accurate interpretation.
Keywords:
Alzheimer's diseaseDiagnosisIncidenceMeta-analysisMild cognitive impairmentSystematic literature review

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