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Updated: Jan 27, 2026

Ultra-long Read Sequencing for Whole Genomic DNA Analysis
Published on: March 15, 2019
Distribution of Distances Between Symmetric Words in the Human Genome: Analysis of Regular Peaks
Carlos A C Bastos1, Vera Afreixo2, João M O S Rodrigues3
1Department of Electronics, Telecommunications and Informatics, IEETA-Institute of Electronics and Informatics Engineering of Aveiro, University of Aveiro, Campus Universitário de Santiago, Aveiro, Portugal. cbastos@ua.pt.
Abstract:
Finding DNA sites with high potential for the formation of hairpin/cruciform structures is an important task. Previous works studied the distances between adjacent reversed complement words (symmetric word pairs) and also for non-adjacent words. It was observed that for some words a few distances were favoured (peaks) and that in some distributions there was strong peak regularity. The present work extends previous studies, by improving the detection and characterization of peak regularities in the symmetric word pairs distance distributions of the human genome. This work also analyzes the location of the sequences that originate the observed strong peak periodicity in the distance distribution. The results obtained in this work may indicate genomic sites with potential for the formation of hairpin/cruciform structures.
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