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Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study.
Ratna Sudha Madempudi1, Jayanthi Neelamraju2, Jayesh J Ahire2
1Centre for Research and Development, Unique Biotech Ltd., Plot No. 2, Phase II, Alexandria Knowledge Park, Hyderabad, Telangana, 500078, India. sudha@uniquebiotech.com.
Probiotics and Antimicrobial Proteins
|March 27, 2019
Summary
Bacillus coagulans Unique IS2 significantly improved bowel movements and stool consistency in adults with functional constipation. This probiotic strain effectively reduced symptoms, offering a promising treatment for constipation.
Area of Science:
- Gastroenterology
- Microbiology
- Clinical Nutrition
Background:
- Functional constipation is a prevalent condition impacting quality of life in adults.
- Probiotics demonstrate potential in alleviating constipation symptoms, with effects being strain-specific.
Purpose of the Study:
- To evaluate the efficacy of Bacillus coagulans Unique IS2 in treating functional constipation in adults.
Main Methods:
- A randomized, placebo-controlled trial involving 100 adult subjects with functional constipation.
- Participants received either 2 billion CFU of B. coagulans Unique IS2 or a placebo daily for 4 weeks.
- Outcomes assessed included treatment success (≥3 spontaneous stools/week), stool consistency, defecation difficulty, and abdominal pain.
Main Results:
- The probiotic group showed a statistically significant increase in bowel movements compared to placebo (p < 0.001).
- 98% of subjects in the probiotic group achieved normal stool consistency versus 74% in the placebo group.
- Significant relief from incomplete evacuation, painful defecation, and abdominal pain was observed in the probiotic group.
Conclusions:
- Bacillus coagulans Unique IS2 effectively reduced symptoms of functional constipation in adults.
- The study highlights the therapeutic potential of this specific probiotic strain for constipation management.
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