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Influence of long-term steroid use on lymphocytes subsets in patients with lupus erythematosus
Karolina Pełka1, Agata Kłosowicz1, Anna Wojas-Pelc1
1Department of Dermatology, Jagiellonian University, Collegium Medicum, Cracow, Poland.
Abstract:
Glucocorticosteroids (GCS) were used for decades to modulate immune system. Numerous studies were performed to evaluate their effects on cell mediated response and humoral immunity.
Aim:
The aim of study was to evaluate the potential associations between chronic use of GCS and immunological tests.
Patients And Methods:
A cohort of patients (n=15) from Department of Dermatology of University Hospital of Cracow, Poland with cutaneous lupus erythematous were identified on individual record review. Flow cytometry was performed to determine the counts of circulating subsets of lymphocytes. Additionally, using nephelometry, serum concentrations of immunoglobulins (i.e. IgA, IgM, IgG) were assessed.
Results:
A cohort of patients (n=15) from Department of Dermatology of University Hospital of Cracow, Poland with cutaneous lupus erythematous were identified on individual record review. Flow cytometry was performed to determine the counts of circulating subsets of lymphocytes. Additionally, using nephelometry, serum concentrations of immunoglobulins (i.e. IgA, IgM, IgG) were assessed.
Conclusions:
A cohort of patients (n=15) from Department of Dermatology of University Hospital of Cracow, Poland with cutaneous lupus erythematous were identified on individual record review. Flow cytometry was performed to determine the counts of circulating subsets of lymphocytes. Additionally, using nephelometry, serum concentrations of immunoglobulins (i.e. IgA, IgM, IgG) were assessed.
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