Related Experiment Video
Updated: Jan 27, 2026
10:28
Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
5.8K
Alternative methods for functional assessment of intermediate coronary lesions
Martyna Zaleska1, Łukasz Kołtowski2, Jakub Maksym1
1First Chair and Department of Cardiology, Medical University of Warsaw, Poland, Poland.
Cardiology Journal
|March 27, 2019
Summary
Fractional flow reserve (FFR) guides heart treatment, but invasive methods are costly and time-consuming. New non-invasive techniques show promise for evaluating coronary artery disease safely and effectively.
Area of Science:
- Cardiovascular medicine
- Interventional cardiology
- Medical imaging
Background:
- Wire-based fractional flow reserve (FFR) is crucial for assessing coronary lesion severity and guiding revascularization.
- FFR-guided treatment improves clinical outcomes but faces adoption barriers due to cost, time, and invasiveness.
Purpose of the Study:
- To review the clinical safety and efficacy of novel, less-/non-invasive methods for FFR assessment.
- To explore techniques like instantaneous wave-free ratio, quantitative flow ratio, and CT-FFR.
Main Methods:
- Review of scientific evidence on computational fluid dynamics (CFD) and 3D lumen reconstruction.
- Analysis of data supporting the clinical utility of non-invasive FFR alternatives.
Main Results:
- Emerging non-invasive methods offer alternatives to wire-based FFR.
- These techniques leverage CFD and advanced imaging for lesion evaluation.
Conclusions:
- Non-invasive FFR assessment methods demonstrate potential clinical safety and efficacy.
- These advancements may overcome limitations of traditional FFR, improving accessibility.
Keywords:
computational fluid dynamicscoronary angiographyfractional flow reservequantitative flow ratioMore Related Videos
Related Concept Videos
01:24Area Computation by the Alternative Coordinate Method
593
The alternative coordinate method, also known as the Shoelace Formula, is a technique for determining the area of a traverse using Cartesian coordinates. This method relies on the sequential arrangement of x and y coordinates for each point of the shape, ensuring accuracy and ease of application.In this approach, each corner's x and y coordinates are listed as fractions, with the x-coordinate as the numerator and the y-coordinate as the denominator. These coordinates are arranged sequentially...
593
01:17In Vitro Drug Dissolution: Alternative Methods
213
Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
213
01:35Disassembly of Intermediate Filaments
2.6K
Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to regulate their disassembly. The IF concentration in the cytoplasm also regulates the disassembly. If the concentration crosses a threshold, it activates the protein kinases in the vicinity, allowing the phosphorylation of IFs.
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...
2.6K
01:31Types of Intermediate Filaments
4.8K
The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...
4.8K
00:57Formation of Intermediate Filaments
3.9K
Intermediate filaments are cytoskeletal proteins with higher tensile strength and flexibility than microfilaments and microtubules. Unlike the other two cytoskeletal proteins, intermediate filament formation lacks the enzymatic activity to hydrolyze nucleotides like ATP and GTP to generate energy for polymerization. Therefore, the formation of intermediate filaments is multistep self-assembly. The involvement of any accessory proteins in intermediate filament formation has not yet been...
3.9K
02:18Alternative RNA Splicing
24.8K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
24.8K