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Updated: Jan 27, 2026

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Differential risk group of developing stroke among older women with gouty arthritis: A latent transition analysis

Hui-Chuan Huang1, Hsueh-Ping Chiang2, Nai-Wei Hsu3

  • 1School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.

European Journal of Clinical Investigation
|March 27, 2019
PubMed

Insights

Diabetes significantly increases stroke risk in women with gout. Managing diabetes and other gout comorbidities early is crucial for reducing future stroke incidence in this population.

Area of Science:

  • Rheumatology
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Gout comorbidities and their sex-specific clinical features are complex.
  • Limited research exists on gout comorbidities specifically within the female population.
  • Understanding comorbidity trajectories is vital for managing gout's impact.

Purpose of the Study:

  • To compare comorbidity aggregation and trajectories in female and male gout patients.
  • To investigate the consequences of these comorbidities, particularly stroke risk.
  • To identify sex differences in gout comorbidity patterns.

Main Methods:

  • Prospective cohort study utilizing Taiwan's National Health Insurance Research Database (2000-2009).
  • Analysis of cardiovascular disease, hyperlipidemia, hypertension, diabetes mellitus (DM), and chronic kidney disease.
  • Latent trajectory analysis to determine comorbidity transition patterns and cumulative stroke incidence (2000-2010).

Main Results:

  • Five distinct comorbidity cluster transition (CT) phenotypes were identified in both sexes.
  • Female gout patients in CT2 predominantly had DM, correlating with a higher stroke risk.
  • Specific comorbidity patterns were observed, with varying persistence and transitions over time.

Conclusions:

  • Diabetes mellitus is a significant risk factor for stroke development in female gout patients.
  • Proactive assessment and management of gout comorbidities, especially DM, can mitigate stroke risk.
  • This study highlights the importance of sex-specific considerations in gout management.
Abstract

Keywords:
comorbiditygoutlatent transition analysisstrokewomen

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