Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

663
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
663
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.4K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.4K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.4K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

195
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
195
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

266
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
266
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

239
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
239

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pediatric oral cavity physiologically based pharmacokinetic model to predict pharmacokinetics of mucoadhesive atropine gel to treat sialorrhea.

Journal of pharmacokinetics and pharmacodynamics·2026
Same author

Shared Decision-Making for Children with Medical Complexity and Their Caregivers in the Perioperative Time.

Pediatric clinics of North America·2026
Same author

Pediatric Oral Cavity Physiologically Based Pharmacokinetic Model to Predict Pharmacokinetics of Mucoadhesive Atropine Gel to Treat Sialorrhea.

Research square·2026
Same author

Sociostructural Determinants of Health for People Living With HIV During the COVID-19 Pandemic: A Policy Brief for Future Global Health Crises.

The Journal of the Association of Nurses in AIDS Care : JANAC·2025
Same author

Utilization of Jumbo-Sized Cups in Conjunction With Dual-Mobility Constructs Does Not Increase Risk of Re-Revision in Revision Hip Arthroplasty.

Arthroplasty today·2025
Same author

Measles Matters: A Clinical Overview and Update.

The Nursing clinics of North America·2025

Related Experiment Video

Updated: Jan 27, 2026

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
13:58

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

Published on: September 26, 2011

32.1K

HIV and aging: A primer for NPs.

Jeffrey Kwong1, Darcel Reyes, Nancy Murphy

  • 1Jeffrey Kwong is a professor and associate dean at Rutgers School of Nursing, Division of Advanced Nursing Practice, Newark, N.J. Darcel Reyes is an assistant professor, program director of the HIV Care Specialization, and editor of the New Jersey HIVLinks newsletter at Rutgers School of Nursing, Newark, N.J. Nancy Murphy is an associate professor at Rutgers School of Nursing, Division of Advanced Nursing Practice, Newark, N.J. Thomas J. Loveless is a clinical assistant professor at Rutgers School of Nursing, Division of Advanced Nursing Practice, Newark, N.J.

The Nurse Practitioner
|March 27, 2019
PubMed
Summary
This summary is machine-generated.

By 2030, 70% of people with HIV will be over 50. Chronic health conditions are now the leading cause of illness in this group, making healthy aging a critical concern. Nurse practitioners are key to supporting this population.

More Related Videos

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
11:10

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

Published on: December 27, 2010

12.8K
Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
08:15

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

9.1K

Related Experiment Videos

Last Updated: Jan 27, 2026

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
13:58

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

Published on: September 26, 2011

32.1K
Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
11:10

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

Published on: December 27, 2010

12.8K
Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
08:15

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

9.1K

Area of Science:

  • Gerontology
  • Public Health
  • Infectious Diseases

Background:

  • An estimated 70% of individuals with human immunodeficiency virus (HIV) will be aged 50 or older by 2030.
  • Chronic conditions such as cardiovascular disease, diabetes mellitus, kidney disease, malignancies, neurocognitive disorders, and osteopenia/osteoporosis are more prevalent in the HIV-positive population.
  • These comorbidities represent the leading cause of morbidity and mortality in individuals aging with HIV.

Purpose of the Study:

  • To highlight the growing demographic of older adults living with HIV.
  • To emphasize the increased burden of chronic conditions in this population.
  • To underscore the essential role of nurse practitioners (NPs) in facilitating healthy aging for individuals with HIV.

Main Methods:

  • Literature review and epidemiological data analysis.
  • Synthesis of current research on aging with HIV and associated comorbidities.
  • Analysis of the role of advanced practice providers in managing chronic conditions.

Main Results:

  • The HIV-positive population is rapidly aging, with a significant increase in those over 50 projected.
  • A high prevalence of multiple chronic conditions significantly impacts the health and quality of life of older adults with HIV.
  • NPs are crucial in providing comprehensive, patient-centered care to manage these complex health needs.

Conclusions:

  • The aging HIV population presents unique and complex healthcare challenges.
  • Effective management of chronic conditions is paramount for improving health outcomes and promoting healthy aging in people with HIV.
  • NPs are integral to the multidisciplinary team, offering specialized care to support this growing demographic.