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Updated: Jan 27, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Therapeutic Drug Monitoring of Everolimus in Oncology: Evidences and Perspectives

Sabrina Falkowski1, Jean-Baptiste Woillard2,3,4

  • 1Department of Oncology, Clinique Chenieux.

Therapeutic Drug Monitoring
|March 27, 2019
PubMed

Insights

Therapeutic drug monitoring (TDM) for everolimus, an mTOR inhibitor, is standard in transplantation but not oncology. This review explores evidence supporting TDM

Area of Science:

  • Pharmacology
  • Oncology
  • Drug Monitoring

Background:

  • Everolimus, an mTOR inhibitor, treats advanced breast, renal, and neuroendocrine cancers.
  • Therapeutic drug monitoring (TDM) is established in transplantation but not routine in oncology for everolimus.
  • Current consensus requires further studies on the clinical utility of everolimus TDM in oncology.

Purpose of the Study:

  • To review existing evidence and perspectives favoring TDM of everolimus in oncology.
  • To discuss the practical management, prerequisites, and pharmacodynamics of everolimus TDM.
  • To provide an outlook on the role of TDM in everolimus cancer treatment.

Main Methods:

  • Review of observational studies on everolimus use in oncology.
  • Analysis of current practices and evidence for TDM.
  • Discussion of pharmacodynamic aspects, including resistance biomarkers and mTOR mutations.

Main Results:

  • Evidence suggests potential benefits of TDM for everolimus in oncology settings.
  • Routine management and prerequisites for TDM implementation are discussed.
  • Pharmacodynamic factors influencing everolimus efficacy and resistance are examined.

Conclusions:

  • Further research is needed to solidify the role of TDM for everolimus in oncology.
  • TDM may offer a valuable tool for optimizing everolimus treatment in cancer patients.
  • Understanding pharmacodynamics is crucial for effective TDM strategies in oncology.

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