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Related Experiment Video

Updated: Jan 27, 2026

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

TAZ Forces Lateral Inhibition.

Joseph G Kern¹, Xaralabos Varelas¹

¹Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.

Developmental Cell

|March 27, 2019

Summary

This summary is machine-generated.

Scientists discovered TAZ, a transcriptional regulator, mediates cell fate specification in zebrafish oogenesis. This process involves lateral inhibition and mechanical cues, revealing new cell communication mechanisms in animal development.

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Last Updated: Jan 27, 2026

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

De Novo Generation of Somatic Stem Cells by YAP/TAZ

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Published on: May 7, 2018

Lateral Root Inducible System in Arabidopsis and Maize

Lateral Root Inducible System in Arabidopsis and Maize

Published on: January 14, 2016

Area of Science:

Developmental Biology
Cell Biology
Molecular Biology

Background:

Cell communication is crucial for specifying cell fate during animal development.
Lateral inhibition is a key mechanism controlling cell fate decisions.

Purpose of the Study:

To identify novel mediators of lateral inhibition in zebrafish oogenesis.
To elucidate the role of mechanical cues in cell fate determination.

Main Methods:

Investigated the function of the transcriptional regulator TAZ.
Utilized zebrafish oogenesis as a model system.
Analyzed cell fate specification through lateral inhibition.

Main Results:

Identified TAZ as a novel mediator of lateral inhibition.
Demonstrated that TAZ directs cell fate through mechanical cues.
Provided new insights into cell communication during oogenesis.

Conclusions:

TAZ plays a critical role in regulating cell fate during zebrafish development.
Mechanical cues are important signaling mechanisms in cell fate specification.
This study uncovers new pathways in developmental cell communication.