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Updated: Jan 27, 2026

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
Control of indigenous quorum quenching bacteria on membrane biofouling in a short-period MBR
Jinhui Huang1, Yanling Gu1, Guangming Zeng1
1College of Environmental Science and Engineering, Hunan University, Changsha, Hunan 410082, China; Key Laboratory of Environmental Biology and Pollution Control, Hunan University, Ministry of Education, Changsha, Hunan 410082, China.
Abstract:
In this paper, the immobilized quorum quenching (QQ) bacteria - microbial bag was added to a short-period membrane bioreactor (MBR) and its antifouling ability and mechanism were studied by monitoring the changes in transmembrane pressure (TMP), along with the production of N-acyl-homoserine lactones (AHLs), extracellular polymeric substance (EPS) and soluble microbial products (SMP). The QQ bacteria showed efficient mitigation of TMP increase in different membrane fouling stages. In the control MBR group, the TMP reached 43 kPa on the 4th day, while in the experimental group, TMP of QQ-MBR was only 18 kPa at the same time. The detection result of EPS and SMP content of protein and polysaccharide in MBRs showed that QQ bacteria had significant inhibitory effects on EPS and SMP. Also, the QQ bacterial exhibited excellent AHLs degradation rate in MBR reaction tank.
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