Related Experiment Video

Updated: Jan 27, 2026

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
09:28

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Published on: September 16, 2020

9.3K

Can IL-33 and Endocan be New Markers for Retinopathy of Prematurity?

Ufuk Cakir1, Cuneyt Tayman1, Cigdem Yucel2

  • 1Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.

Combinatorial Chemistry & High Throughput Screening
|March 28, 2019
PubMed

Insights

Interleukin-33 (IL-33) and endocan show promise as sensitive biomarkers for predicting severe Retinopathy of Prematurity (ROP). Their serum levels decreased significantly after laser treatment in infants with ROP.

Area of Science:

  • Neonatal ophthalmology
  • Vascular biology
  • Biomarker discovery

Background:

  • Retinopathy of Prematurity (ROP) is a condition characterized by abnormal retinal vessel proliferation in premature infants.
  • Early diagnosis and monitoring are crucial for managing ROP and preventing vision loss.

Purpose of the Study:

  • To evaluate the diagnostic and follow-up potential of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), interleukin-33 (IL-33), and endocan in Retinopathy of Prematurity.
  • To identify novel biomarkers for predicting severe ROP.

Main Methods:

  • A prospective cohort study involving 146 preterm infants (gestational age ≤32 weeks, birth weight ≤1500g) diagnosed with ROP.
  • Measurement of VEGF, IGF-1, IL-33, and endocan levels in cord blood and serum before and after treatment in ROP and control groups.

Main Results:

  • Cord blood VEGF was higher, while IGF-1 was lower in the ROP group compared to controls.
  • IL-33 and endocan levels in cord blood were similar between groups.
  • Serum IL-33, VEGF, and endocan levels were elevated before laser treatment and decreased significantly post-treatment.

Conclusions:

  • Serum IL-33 and endocan levels may serve as sensitive novel markers for predicting severe ROP.
  • These biomarkers warrant further investigation for clinical application in ROP management.
Abstract

Keywords:
Insulin-like growth factor-1interleukin-33laser treatmentretinaretinopathy of prematurityvascular endothelial growth factor.

More Related Videos

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.2K
Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies12:28

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

4.2K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
563
Mutations01:39

Mutations

Overview
94.5K
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
14.1K
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
11.8K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.6K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
16.2K