Related Experiment Video

Updated: Jan 27, 2026

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
05:16

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors

Published on: February 19, 2022

6.5K

Mutational Testing in Gastrointestinal Stromal Tumor

Yu Wang1, Jerry Call1

  • 1The Life Raft Group, 155 US-46 Wayne, NJ 07470, United States.

Current Cancer Drug Targets
|March 28, 2019
PubMed

Insights

Mutational testing is essential for guiding targeted cancer therapy in gastrointestinal stromal tumors (GIST). Despite recommendations, many GIST patients do not receive mutation-guided management, highlighting a gap in care.

Area of Science:

  • Oncology
  • Genetics
  • Gastroenterology

Background:

  • Targeted cancer therapies are designed for tumors with specific genetic profiles.
  • Gastrointestinal stromal tumors (GIST) are now recognized as distinct mesenchymal tumors with known molecular characteristics.
  • Mutational testing is critical for effective targeted therapy selection in cancer management.

Purpose of the Study:

  • To review the current landscape of mutation-guided therapy for GIST.
  • To discuss various methods for mutational testing in GIST.
  • To highlight recent advancements in targeted therapies for GIST based on specific mutations.

Main Methods:

  • Literature review of GIST research.
  • Analysis of clinical guidelines and recommendations (e.g., NCCN).
  • Summary of current and emerging GIST mutational testing techniques.

Main Results:

  • GIST has well-defined molecular characteristics, enabling targeted treatments.
  • National Comprehensive Cancer Network (NCCN) guidelines recommend mutational testing for GIST.
  • A significant number of GIST patients still lack mutation testing or mutation-guided management.

Conclusions:

  • Mutation-guided therapy is crucial for optimizing GIST treatment outcomes.
  • There is a need to improve the uptake of mutational testing in GIST patient care.
  • Advances in targeted therapies offer new hope for GIST patients with specific mutations.
Keywords:
Gastrointestinal stromal tumorKITPDGFRAmutation-guided cancer managementmutational testingsarcoma.

More Related Videos

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

2.6K
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

25.0K

Related Concept Videos

Mutations01:39

Mutations

Overview
94.5K
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
44.2K
Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
39.8K
Anatomy of the Gastrointestinal System01:26

Anatomy of the Gastrointestinal System

The human digestive system is an intricate and essential network for nutrient absorption and waste elimination. It encompasses the gastrointestinal (GI) tract and several accessory organs.
Here's a detailed walkthrough of this complex system:
2.7K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
63.7K
Histology of the Gastrointestinal (GI) Tract01:20

Histology of the Gastrointestinal (GI) Tract

The GI tract, from beginning to end, is made up of four continuous tissue layers that adjust their structure according to their specific roles. These layers, from innermost to outermost, are known as the mucosa, submucosa, muscularis, and serosa, which are continuous with the mesentery.
The mucosa is sometimes called a mucous membrane due to its mucus-secreting features. This membrane is composed of epithelium, which directly interacts with ingested substances, and the lamina propria, a layer...
3.4K