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Related Concept Videos

Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Pleura of the Lungs01:13

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Related Experiment Video

Updated: Jan 27, 2026

Orthotopic Left Lung Transplantation in Rats
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Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

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[Research progress in lung transplantation].

Meng Sun1, Zongmei Wen

  • 1Shanghai Affiliated Hospital of Tongji University, Shanghai 200433, China. Corresponding author: Wen Zongmei,

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
|March 28, 2019
PubMed
Summary
This summary is machine-generated.

Lung transplantation faces challenges like rejection and infection. Addressing these critical issues in lung transplant recipients can improve patient survival and treatment outcomes.

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Area of Science:

  • Cardiovascular and Respiratory System Science
  • Surgical and Transplant Medicine

Background:

  • Lung transplantation is the sole curative option for end-stage lung disease.
  • Significant obstacles impede lung transplant development and patient prognosis.

Purpose of the Study:

  • To identify major bottlenecks in lung transplantation.
  • To explore factors affecting lung transplant patient survival.
  • To present novel clinical treatment strategies.

Main Methods:

  • Review of critical challenges in lung transplantation.
  • Analysis of factors impacting patient survival post-transplant.
  • Evaluation of current response measures.

Main Results:

  • Identified key issues: acute rejection, infection, primary graft dysfunction (PGD), ischemia/reperfusion injury.
  • Highlighted impact of surgical techniques, anesthesia, donor factors, and cardiopulmonary bypass/ECMO.
  • Recognized recipient pathogenesis as a critical factor.

Conclusions:

  • Addressing identified bottlenecks is crucial for advancing lung transplantation.
  • Novel strategies are needed to overcome current limitations and improve patient outcomes.