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Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
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[Electrocardiographic and hemodynamic profile of patients with psychotic disorder]
Insights
Cardiac abnormalities are common in patients with mental disorders who are not taking medication. Lower thyroid hormone levels were linked to these electrocardiographic changes, warranting further research.
Area of Science:
- Cardiology
- Psychiatry
- Endocrinology
Background:
- Elevated cardiac mortality observed in individuals with mental disorders.
- Potential link between cardiovascular risk and intrinsic psychiatric disease factors.
- Need for studies on drug-naïve patients due to antipsychotic medication effects.
Purpose of the Study:
- Assess electrocardiographic and hemodynamic profiles in drug-naïve or drug-free psychiatric patients.
- Identify clinical and biological factors associated with electrocardiographic abnormalities.
Main Methods:
- Descriptive, evaluative, cross-sectional study design.
- Inclusion of drug-naïve or drug-free patients (minimum 2 months).
- Comprehensive clinical, biological, and electrocardiographic evaluation at admission.
Main Results:
- 44% of participants exhibited asymptomatic electrocardiographic abnormalities.
- Lower serum thyroid hormone levels observed in subjects with abnormalities (P=0.066).
- 12% of the population presented with orthostatic hypotension.
Conclusions:
- Electrocardiographic and hemodynamic abnormalities are prevalent in drug-free/naïve patients with psychotic disorders.
- Association between electrocardiographic abnormalities and low thyroxin levels requires further investigation.
Introduction:
Cardiac mortality among patients diagnosed with mental disorders is higher compared to the general population. Some authors suggest that cardiovascular risk is related to intrinsic factors specific to psychiatric disease. Nevertheless, the interpretation of these results is limited by the concomitant prescription of antipsychotics which have a cardiovascular effect. Studies evaluating the hemodynamic and electrocardiographic profile of drug naïve or drug-free patients suffering from mental disorders remain few.
Aims:
The aims of this work were to study the electrocardiographic and hemodynamic profile of drug naïve or drug-free patients with mental disorders and to determine clinical and biological factors associated with any electrocardiographic abnormalities.
Subjects And Methods:
It was a descriptive and evaluative cross-sectional study. We enrolled drug naïve or drug-free patients for at least two months. All subjects were inpatients and had at admission clinical, biological and electrocardiographic evaluation.
Results:
Forty-four percent of the sample had asymptomatic electrocardiographic abnormalities. These subjects had lower serum thyroid hormone levels compared to healthy group (P=0.066). Hemodynamic profile showed that 12% of the population had orthostatic hypotension.
Conclusion:
Electrocardiographic and hemodynamic abnormalities are common among drug-free or drug naïve patients diagnosed with psychotic disorders. The association of electrocardiographic abnormalities with low levels of thyroxin requires more investigation.
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