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Radiogenomics in the Era of Advanced Radiotherapy.

M R S Brothwell1, C M West2, A M Dunning3

  • 1Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|March 28, 2019
PubMed
Summary
This summary is machine-generated.

Radiogenomics research links genetic variations to radiotherapy toxicity. This field aims to personalize cancer treatment by combining genetic, clinical, and treatment factors for better tumor control and reduced side effects.

Keywords:
Genome-wide association studiesradiogenomicsradiotherapy toxicity

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Area of Science:

  • Oncology
  • Genetics
  • Radiotherapy

Background:

  • Radiogenomics investigates genetic influences on individual differences in radiotherapy toxicity.
  • The field has advanced from candidate gene studies to genome-wide association studies and prospective validation.

Purpose of the Study:

  • To discuss the evolution and recent developments in radiogenomics.
  • To highlight the potential of radiogenomics in personalizing cancer treatment.

Main Methods:

  • Review of radiogenomics studies, including candidate gene studies, genome-wide association studies, and meta-analyses.
  • Discussion of advancements in genotyping and whole-genome sequencing.

Main Results:

  • Radiogenomics has evolved significantly, with increasingly sophisticated and affordable genotyping.
  • Prospective validation studies are emerging, indicating the field's translational progress.

Conclusions:

  • The ultimate goal is to tailor radiotherapy to individual patients using a combination of genetic, clinical, and treatment data.
  • Personalized treatment aims to maximize tumor control while minimizing acute and long-term toxicity.