Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pharyngitis

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Synergistic Induction of Neutrophilic Inflammatory Programs by <i>Staphylococcus aureus</i> and Cigarette Smoke in Airway Epithelial Cells.

Immune network·2026

Same author

Age-Dependent Role of Cough Hypersensitivity in Transition to Refractory Chronic Cough.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026

Same author

Expiratory pulmonary vascular retention on computed tomography as a marker of asthma severity.

The Journal of allergy and clinical immunology·2026

Same author

GGT-triggered self-immolative dexamethasone-oligopeptide prodrug nanoparticles ameliorate hepatic fibrosis via dual anti-inflammatory/immunomodulatory pathways with minimized systemic toxicity.

Journal of nanobiotechnology·2026

Same author

NIPT detects occult maternal malignancies via cfDNA aberration profiling: a case report.

Frontiers in medicine·2026

Same author

Burden of Chronic Cough and Refractory/Unexplained Chronic Cough in South Korea: A Multicenter, Observational Study (CHORUS).

Lung·2026

Search research articles

Related Experiment Video

Updated: Jan 27, 2026

Methods for Detecting Cough and Airway Inflammation in Mice

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Chronic cough in the elderly.

Woo-Jung Song¹, Ha-Kyeong Won¹, Jin An¹

¹Airway Sensation and Cough Research Laboratory, Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Pulmonary Pharmacology & Therapeutics

|March 28, 2019

Summary

Chronic cough is more complex in older adults due to comorbidities and potential reflex changes. Current guidelines often overlook these elderly-specific challenges, necessitating tailored diagnostic and therapeutic strategies.

Keywords:

Aging Comorbidity Cough Cough hypersensitivity Elderly

More Related Videos

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Published on: January 10, 2025

Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice

Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice

Published on: October 3, 2025

Related Experiment Videos

Last Updated: Jan 27, 2026

Methods for Detecting Cough and Airway Inflammation in Mice

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Published on: January 10, 2025

Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice

Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice

Published on: October 3, 2025

Area of Science:

Geriatrics
Pulmonology
Clinical Medicine

Background:

Chronic cough is a common condition, particularly prevalent in older adults (≥65 years).
Elderly patients often present with multiple comorbidities, increasing clinical heterogeneity and diagnostic/therapeutic challenges.
Reduced cough reflex sensitivity, potentially due to central nervous system conditions, is another concern in this population.

Purpose of the Study:

To determine if chronic cough is more heterogeneous in the elderly compared to younger adults.
To identify additional considerations for diagnosing and treating chronic cough in the elderly population.

Main Methods:

This review synthesizes current literature on chronic cough in the elderly.
It addresses specific clinical questions regarding the heterogeneity and management of chronic cough in older adults.

Main Results:

Chronic cough exhibits greater heterogeneity in the elderly due to comorbidities and potential alterations in cough reflex sensitivity.
Existing clinical practice guidelines for chronic cough inadequately address elderly-specific issues.
The aging global population suggests an increasing burden of chronic cough in older adults.

Conclusions:

Chronic cough management in the elderly requires specialized approaches due to increased complexity and heterogeneity.
Further research and guideline development are needed to address the unique needs of older adults with chronic cough.