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Apical constriction is necessary for crypt formation in small intestinal organoids

Leonie Hartl1, Guizela Huelsz-Prince1, Jeroen van Zon1

  • 1AMOLF, Science Park 104, 1098 XG Amsterdam, the Netherlands.

Developmental Biology
|March 28, 2019
PubMed
Summary

Changes in cell shape, not just proliferation, drive the formation of crypts in small intestinal organoids. Myosin II activity causes cells to constrict, initiating bud formation for crypt development.

Keywords:
Apical constrictionBlebbistatinCrypts of LieberkühnNon-muscle myosin IISmall intestine organoids

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