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Updated: Jan 27, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Nagarines A and B, two novel 8,15-seco diterpenoid alkaloids from Aconitum nagarum
Tianpeng Yin1, Yan Shu2, Hao Zhou2
1Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China; Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zunyi Medical University Zhuhai Campus, Zhuhai 519041, China.
Abstract:
Two novel 8,15-seco C19-diterpenoid alkaloids, nagarines A (1) and B (2), were isolated from the roots of Aconitum nagarum Stapf (Ranunculaceae), a folk herbal medicine used to treat rheumatism and arthritis in Southwestern China, Northern Burma and Northeastern India. They are the first C19-diterpenoid alkaloids possessing unprecedented opened D ring formed by the cleavage of the bond between C-8 and C-15. Compounds 1 and 2 showed certain inhibition activities of interleukin-6 in LPS-activated RAW 264.7 cells with IC50 values of 72.63 ± 0.39 μM and 52.98 ± 0.50 μM, respectively.
