Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

915
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
915
Ribosomes01:27

Ribosomes

75.3K
Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
75.3K
Anatomy of the Circulatory System02:03

Anatomy of the Circulatory System

97.9K
The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.
97.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peranal Endoscopic Myectomy for Lower Rectal Lesions with Severe Fibrosis: A Retrospective Study.

Digestive diseases and sciences·2026
Same author

Safety and Efficacy of Oral Tacrolimus Induction Therapy in Elderly Patients with Ulcerative Colitis: A Subanalysis of a Large Multicenter Retrospective Cohort Study.

Gerontology·2026
Same author

A Case of Autoimmune Polyendocrine Syndrome Type 3C with Warm-type Autoimmune Hemolytic Anemia which Developed during Treatment for Hashimoto's Thyroiditis.

Internal medicine (Tokyo, Japan)·2026
Same author

Metagenomic analysis of the intragastric and oral microbiome associated with gastric carcinogenesis after Helicobacter pylori eradication.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·2026
Same author

Report on the First WEGECA Meeting: Women Endoscopists for Global Exchange and Career Advancement.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society·2026
Same author

Questionnaire Survey on the Current Status of Advanced Therapy for Inflammatory Bowel Disease in Asia.

Digestion·2025

Related Experiment Video

Updated: Jan 27, 2026

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.7K

[Carcinogenesis and Gut Microbiota].

Akiko Shiotani1, Shinya Fukushima, Hiroshi Matsumoto

  • 1Division of Gastroenterology, Dept. of Internal Medicine, Kawasaki Medical School.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|March 28, 2019
PubMed
Summary
This summary is machine-generated.

Gut microbiota plays a key role in cancer development and progression. Imbalances in gut bacteria (dysbiosis) can promote tumorigenesis and impact cancer immunotherapy effectiveness.

More Related Videos

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.8K
Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization
08:30

Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization

Published on: June 1, 2018

10.0K

Related Experiment Videos

Last Updated: Jan 27, 2026

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.7K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.8K
Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization
08:30

Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization

Published on: June 1, 2018

10.0K

Area of Science:

  • Microbiome research
  • Metabologenomics
  • Cancer biology

Background:

  • Gut microbiota significantly impacts host health, immunostasis, and gut homeostasis.
  • Microbial dysbiosis is linked to increased tumorigenesis, epithelial carcinogenesis, and tumor progression.
  • Altered metabolic properties and inflammatory processes driven by gut bacteria contribute to cancer.

Purpose of the Study:

  • To explore the role of gut microbiota in carcinogenesis.
  • To understand how gut microbiota influences cancer immunotherapy.
  • To investigate the association between specific bacteria and colon cancer development.

Main Methods:

  • Metabologenomics techniques
  • Analysis of bacterial populations and their metabolic properties
  • Investigating inflammatory pathways and immune responses (e.g., Th17 cells, NLRP6 inflammasome)

Main Results:

  • Dysbiosis can stimulate tumorigenesis and promote tumor progression via altered metabolism and inflammation.
  • Specific bacteria like enterotoxigenic Bacteroides fragilis (ETBF) and Fusobacterium nucleatum (F. nucleatum) are implicated in colorectal cancer.
  • Gut microbiota composition influences the efficacy and toxicity of cancer immunotherapies, including immune checkpoint inhibitors (PD-1, CTLA-4).

Conclusions:

  • Gut microbiota is a critical factor in both cancer development and response to immunotherapy.
  • Targeting or modulating gut microbiota may offer novel therapeutic strategies for cancer.
  • Further research into the complex interactions between microbes, host immunity, and cancer is warranted.