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[Proteinuria in Patients with Gastric Cancer Treated with Ramucirumab]

Yutaka Kimura1, Jota Mikami, Yoichi Makari

  • 1Dept. of Surgery, Kindai University Faculty of Medicine.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|March 28, 2019
PubMed
Abstract

Insights

Ramucirumab treatment in advanced gastric cancer commonly causes proteinuria. The protein/creatinine ratio in single urine samples is a useful indicator, especially for higher protein levels (2+ to 4+).

Area of Science:

  • Oncology
  • Nephrology
  • Pharmacology

Background:

  • Ramucirumab, an antiangiogenic agent, is associated with proteinuria as a common adverse effect.
  • Proteinuria assessment is crucial for patients receiving ramucirumab therapy.
  • Advanced gastric cancer patients treated with ramucirumab require monitoring for renal side effects.

Purpose of the Study:

  • To retrospectively evaluate proteinuria in advanced gastric cancer patients treated with ramucirumab.
  • To clarify the clinical significance of the protein/creatinine ratio using single urine samples.
  • To establish a reliable method for assessing ramucirumab-induced proteinuria.

Main Methods:

  • Retrospective analysis of 23 patients with advanced gastric cancer treated with ramucirumab.
  • Qualitative analysis of 199 urinalysis specimens to determine urine protein levels.
  • Comparison of urine protein qualitative examination results with protein/creatinatin ratios.

Main Results:

  • Proteinuria occurred in 43.5% of patients (grade 1: 26.1%, grade 2: 8.7%, grade 3: 8.7%).
  • A protein/creatinine ratio over 2 was observed in 12.5% of 2+ and 71.4% of 3+ or 4+ urine protein qualitative results.
  • Lower protein/creatinine ratios (<2) were associated with negative to 1+ urine protein levels.

Conclusions:

  • The protein/creatinine ratio is a valuable tool for assessing proteinuria in ramucirumab-treated gastric cancer patients.
  • Qualitative urine protein examination results of 2+, 3+, or 4+ warrant further investigation with the protein/creatinine ratio.
  • This ratio aids in the clinical management and monitoring of ramucirumab-related adverse events.

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